Estimation of glomerular filtration rate using cystatin C
نویسندگان
چکیده
منابع مشابه
Cystatin C for glomerular filtration rate estimation: coming of age.
Assessment of glomerular filtration rate (GFR) is essential for clinical practice. GFR is difficult to measure [measured GFR (mGFR)]; instead it is estimated [estimated GFR (eGFR)] by use of the serum concentration of endogenous filtration markers. However, all endogenous filtration markers are affected by factors other than GFR (non-GFR determinants), including generation, renal tubular reabso...
متن کاملEstimation of glomerular filtration rate using serum cystatin C in overweight and obese subjects.
BACKGROUND Obesity and overweight are strong independent risk factors for chronic kidney disease (CKD). Using serum creatinine-based estimated glomerular filtration rate (eGFR) equations in these subjects may be inaccurate. On the other hand, cystatin C-based eGFR equations may overestimate CKD prevalence as recent findings suggest an association of cystatin C with obesity. The objective of thi...
متن کاملSERUM CYSTATIN C AS A NEW MARKER OF GLOMERULAR FILTRATION RATE (GFR)
Cystatin C is a 13 KD basic protein that is a member of the cystatin superfamily of cysteine protease inhibitors. The cystatin C gene seems to be a house keeping gene, which is compatible with a stable production rate of cystatin C by most cells. This protein is freely filtered through the glomerulus and almost completely reabsorbed and catabolized by proximal tubular cells. Because of the...
متن کاملGlomerular filtration rate estimation using cystatin C alone or combined with creatinine as a confirmatory test.
BACKGROUND Glomerular filtration rate (GFR) estimating equations using the combination of creatinine and cystatin C (eGFRcr-cys) are more accurate than equations using either alone (eGFRcr or eGFRcys). New guidelines suggest measuring cystatin C as a confirmatory test when eGFRcr may be inaccurate, but do not specify demographic or clinical conditions in which eGFRcys or eGFRcr-cys are more acc...
متن کاملCystatin C: an improved estimator of glomerular filtration rate?
BACKGROUND Glomerular filtration rate (GFR) is routinely assessed by measuring the concentrations of endogenous serum markers such as blood urea nitrogen and serum creatinine (SCr). Although widely used, these endogenous markers are not ideal and do not perform optimally in certain clinical settings. The purpose of this review is to critically review the potential utility of cystatin C (CysC), ...
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ژورنال
عنوان ژورنال: Annales de Biologie Clinique
سال: 2019
ISSN: 0003-3898
DOI: 10.1684/abc.2019.1456